As you digest the milk thistle, certain plant compounds in it begin to mimic the physiological functions of estrogen. It’s unclear what benefits, if any, it may have in the body, but it’s sometimes used as a … There isn't enough reliable information available to know if milk thistle is safe to apply to the skin or inject into the body. serving. My periods vary between being very light and very heavy, with a gap of anything from four days to two months - it's different every time. Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. Supplements containing extracts of the silymarin-phosphatidylcholine compound are generally limited to 200 to 400 milligrams a day, while herbal tinctures and liquid extracts of milk thistle often include recommended dosages on their labels according to the level of dilution. Milk thistle is mainly a plant with long spiny leaves. In seasonal affective disorder (SAD) is associated with winter depression Typically, these individuals not only feel depressed they also feel tried, slow down, and generally oversleep, overeat, and crave carbohydrates in the winter. It’s a gentle laxative that helps increase bowel movements. It is a mixture of flavonoids with powerful antioxidant properties. When a woman’s estrogen levels are low (like during menopause and postmenopause), milk thistle may have a slight estrogenic effect. Mohd Fozi NF, Mazlan M, Shuid AN, Isa Naina M. Milk thistle: a future potential anti-osteoporotic and fracture healing agent. So, milk thistle extracts block the negative effects of estrogen on breast and uterine tissue, while acting in a beneficial way to improve bone health. A Web Experience brought to you by LEAFtv, The University of Maryland Medical Center; Milk Thistle; Steven Ehrlich; March 2009. Always talk to your doctor before taking any herbal supplement that could have an unbalancing effect on your hormone levels. The liver has the important job of detoxifying the body, and that includes removing excess estrogen. Milk thistle can help with some forms of cancer-related to the hormone estrogen. Milk thistle has structural relation to compounds demonstrated active on liver metabolic processes, leading to speculation milk thistle reduces blood sugar. The effectiveness of drugs that are broken down by the same enzymes that break down milk thistle may also be affected. Vitamin D is also an important consideration. For more information, please see the completely revised and updated 3rd edition of The Encyclopedia of Natural Medicine. You can harvest these and extract the seeds by removing the fluffy fibers surrounding them. Milk thistle extract has a high amount of silymarin (between 65–80%) that has been concentrated from the milk thistle plant. If you are taking prescribed medications, talk to your doctor before taking milk thistle. The typical dosage for silybin phytosome is 80 to 120 mg two to three times daily between meals. 2011 May;(565):1-177. Commonly available in capsule, liquid extract and tincture form, milk thistle has a variety of estrogen-like properties that may worsen certain health conditions sensitive to estrogen, such as endometriosis. Can Green Tea Affect Liver Function Test Results? What Exactly Does PQQ Do? Am J Med 2002;113:506-15. As it relates to milk thistle extract (silymarin), there are warnings out in the marketplace that women avoid milk thistle extract as it increases the risk of breast cancer and has estrogenic effects. On the flip side, many phytoestrogens are able to act on bone metabolism in a very positive manner. It’s not really a myth, no. Some women find this helpful for symptoms like hot flashes and insomnia. Milk thistle as a tea is generally not very well absorbed. “There was no evidence of carcinogenic activity.”. Milk thistle is an herbal supplement sometimes recommended for certain health conditions. Further examination has in concluded the effects on liver glucose metabolism do have a blood sugar lowering effect. Not at all, in fact telling women to avoid milk thistle extract is doing them a disservice. Natl Toxicol Program Tech Rep Ser. Just as the media often creates stories on natural products that lack critical thinking and are fraught with incorrect conclusions, sometimes marketers of dietary supplements make the same mistake. Phytother Res. Milk thistle can interact with some chemotherapy drugs — check with your doctor before you start taking it. If you take prescription medications, ask your doctor or pharmacist about possible interactions before you begin to take milk thistle. Cancer Treat Rev. Milk thistle extractis LIKELY SAFE when taken by mouth for most adults. It is one of the best plants for liver health. These sorts of early studies have to be interpreted with great caution as they can produce misleading results because of dosage, metabolism, and concentration as well as the strain of rodent used. National Toxicology Study Group. The standard dosage for a milk thistle preparation is based on its silymarin content (70–210 milligrams three times daily). Melatonin supplementation is thought to improve SAD because it increases brain melatonin levels, but it may also suppress cortisol secretion.Take 3-5 mg 45 minutes before retiring. During Breastfeeding and Pregnancy: Consumption of milk thistle during breastfeeding and pregnancy is not recommended as it creates many problems and allergies in the body that may affect the health of the mother and the baby. Preclinical studies with milk thistle extracts are showing tremendous promise in doing just that. Ces personnes éprouvent des nausées, effet laxatif, maux d'estomac et les brûlures d'estomac. The warning is based solely upon selected initial in vitro (test tube) and animal models from several years ago. Silymarin shows potent antioxidant herb that may modulate multiple genes in favour of helping to build bone and prevent bone loss. If however you have run low on one, please text me and il process the order offline for you. Commonly available in capsule, liquid extract and tincture form, milk thistle has a variety of estrogen-like properties that may worsen certain health conditions sensitive to estrogen, such as endometriosis. Milk thistle is an herbal supplement sometimes recommended for certain health conditions. Jacobs BP, Dennehy G, Ramirez J, et al. Consult your doctor. The dosages used are simply not possible to achieve in humans taking milk thistle extract (e.g., female rates were given a daily dose of 2,750 mg of milk thistle extract per 2.2 pounds body weight). Milk thistle seed extract is known to have estrogenic effects and effects on memory by estrogen have been reported. So what did the results show? There is simply a misguided warning. Bosch-Barrera J, Menendez JA. Milk thistle is drought resistant and needs very little watering. Milk thistle works very well for me in an unexpected way - on my hormones! Milk thistle components have been shown to exert dual effects on bone health by preventing the breakdown of bone by cells known as osteoclasts while at the same time improving the building of bone by osteoblasts. He is a licensed yoga and martial arts instructor whose work regularly appears in “Metabolism,” “Verve” and publications throughout the East Coast. Milk thistle may cause a rash or lead to severe allergic reaction. Extracts from the Milk Thistle plant can act as estrogen. The dosage for dried milk thistle seeds is 12 to 15 g daily. Curr Drug Targets. PQQ is an extremely potent antioxidant that is able to carry out the role of an antioxidant in the body more than 20,000 times—which is a rare thing. Milk thistle is a cleansing herb for the liver that assists with the breakdown of toxins. The most comprehensive and authoritative evaluation on the safety of milk thistle extract was conducted by the National Toxicology Program of the United States Department of Health and Human Services. Again, milk thistle extract is extremely well tolerated and is free of significant side effects. This study administered milk thistle extracts at varying dosages to different strains of mice and rats for periods up to two years, the human equivalent of lifelong exposure. Milk thistle also reduces inflammation throughout the body, which means it can help to relieve the pain caused by endometriosis. Try a tea or infusion consumed daily. 2010 Oct;24(10):1423-32. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Although many variables may be responsible for SAD, insufficient light exposure is the most logical explanation. Milk thistle seeds only take only around two weeks to germinate. The effects of plant compounds often referred to as “phytoestrogens” like those in in ground flaxseeds, nuts and seeds, soy, many fruit and medicinal plants on estrogen receptors and metabolism is quite complex. Because of its estrogen-stimulating properties, milk thistle is not recommended for individuals who have been diagnosed with certain estrogen-sensitive cancers, such as breast cancer. Silymarin protects the liver by: • Acting as a direct antioxidant and free radical scavenger. Milk thistle plays a key role in preventing and reducing the symptoms of endometriosis by supporting liver function. I was very tired all the time; very irritable, and very angry. Back in the 1500s, John Gerard wrote that this plant was “the best remedy against melancholy.” While that exact milk thistle benefit is a bit up in the air these days, there are some other benefits that are more bound in science. Green tea provides about the same amount per 4-oz. There is no existing evidence that milk thistle extract possesses any negative estrogenic effects in humans and the existing preclinical studies overwhelmingly shows it may have tremendous protective effects against breast cancer as well as osteoporosis. Are There Any Food Sources of PQQ? These compounds, along with other flavonoids, may also inhibit cancer cells from dividing and reproducing. Cancer Lett. On the show I discussed the failure of conventional medicine to address the underlying issues in many health conditions offering little more than drugs as biochemical “band aids.”. Interestingly, female rats demonstrated decreased breast (mammary) cancer and male rats showed decreased liver cancer with milk thistle extract. This helps a lot to increase the breast size as various hormones, especially estrogen are processed by the liver. Liver health is vital for hormonal balance. For example, other antioxidants, such as vitamin C, are only able to accomplish this “cycling” process about four times. It would be like a woman taking 192,500 mg of milk thistle extract each day instead of the recommended 150 to 300 mg. DIM & Milk Thistle need to be used together in order to support your bodies liver correctly. How to Make Half-and-Half With Plain Milk. For this reason, standardized extracts are preferred. Supports the liver while helping to clear excess estrogen. Talk to your doctor before adding any milk thistle products to your daily routine. Particularly PPQ-rich foods include parsley, green peppers, kiwi, papaya, and tofu. Silymarin is an antioxidant compound taken from milk thistle seeds. Looking at the scientific literature, the overwhelming majority of studies show positive results in breast cancer models as well as those on bone metabolism and zero estrogenic effects have been noted in clinical trials in humans. Milk thistle may interfere with the effects of estrogen replacement therapy and oral contraceptives due to its possible estrogenic effects. What Are the Side Effects of Using Breast Enlargement Pills? 2013 Dec;14(14):1659-66. There is also concern that milk thistle might have estrogenic effects. Milk thistle’s estrogen -like effect may also have some usefulness for men with prostate cancer. While these amounts appear to be sufficient in helping our cells carry out their basic functions, research indicates that boosting PQQ through supplementation can produce some amazing effects. Milk thistle sometimes causes a laxative effect. Milk thistle is a great natural resource for detoxing the liver. (87, 192) Silymarin from milk thistle helps protect against glycation in the skin, a natural aging process that contributes to wrinkles. The liver helps … The antidepressant effects of full-spectrum light therapy have been demonstrated in well-monitored, controlled studies in SAD. Phytosomes are a combination of silymarin with phosphatidylcholine molecules to aid their absorption. Though there are many theories as to why, its likely a complex combination of factors including everything from the food that we eat, to the increase in xenoestrogens in our products, and even glyphosate the ubiquitous Monsanto herbicide thats recently come under fire. Estrogen dominance essentially means high levels of estrogen in the body, which are not being pr… The therapeutic effect of milk thistle extracts in these disorders has been confirmed by biopsy as well as by clinical and laboratory data. 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